For most patients with type 1 diabetes, the worst part of the disease is tolerate needle after needle, both for glucose measurement and to deliver insulin. These review article discusses, in brief the novel and emerging technologies that are insulin pills, Insulin analogues, insulin complement, implantable insulin pump and disposable insulin jewel pump. Relatively, a large percentage of world population is affected by diabetes mellitus, out of which approximately 5-10% with type 1 diabetes while the remaining 90% with type 2. Insulin administration is essential for type 1 patients while it is required at later stage by the patients of type 2. Current insulin delivery systems are available as transdermal injections which may be considered as invasive. Several non-invasive approaches for insulin delivery are being pursued by pharmaceutical companies to reduce the pain, and hypoglycemic incidences associated with injections in order to improve patient compliance, while any novel insulin delivery system requires health authority’s approval, to provide long term safety profile and insuring patient’s acceptance. In the last two decades, concept of insulin therapy by multiple dose injection has undergone a miraculous change. Needle-free insulin delivery appeared to be a wonderful approach, and its al lure rested in being comfortable and safe. In today's era, insulin delivery by alternative route is a topic of current interest in the design of drug delivery system. Major global pharmaceutical companies are showing encouraging progress in their attempts to develop alternative insulin delivery technologies.
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